ANHYDROUS LEVOFLOXACIN: INTRIGUING CRYSTAL STRUCTURES SOLVED BY IN SITU X-RAY POWDER DIFFRACTION
Featuring Prof. Dr. Fabio Furlan Ferreira, Universidade Federal do ABC – UFABC, Santo André, SP, Brazil
Levofloxacin is an antibiotic agent belonging to the fluoroquinolones’ class. In solid-state, it is commonly found in two hydrate forms, with known crystal structures, and several solvated and anhydrous forms are claimed in patents. Until recently, the latter crystal structures were not known. A crystal structure prediction (CSP) work assigned a possible space group and unit cell parameters for the polymorphic α form of levofloxacin. Using high-temperature data collected on a STOE furnace, we could successfully determine the crystal structures of two anhydrous forms: α and γ. In this talk, Prof. Dr. Fabio Furlan Ferreira will present some details about this research, emphasizing some good discussions in the literature started just after their work.