ANHYDROUS LEVOFLOXACIN: INTRIGUING CRYSTAL STRUCTURES SOLVED BY IN SITU X-RAY POWDER DIFFRACTION

Featuring Prof. Dr. Fabio Furlan Ferreira, Universidade Federal do ABC – UFABC, Santo André, SP, Brazil

Levofloxacin is an antibiotic agent belonging to the fluoroquinolones’ class. In solid-state, it is commonly found in two hydrate forms, with known crystal structures, and several solvated and anhydrous forms are claimed in patents. Until recently, the latter crystal structures were not known. A crystal structure prediction (CSP) work assigned a possible space group and unit cell parameters for the polymorphic α form of levofloxacin. Using high-temperature data collected on a STOE furnace, we could successfully determine the crystal structures of two anhydrous forms: α and γ. In this talk, Prof. Dr. Fabio Furlan Ferreira will present some details about this research, emphasizing some good discussions in the literature started just after their work.

55 min.