Running a service crystallography lab often requires meeting two contradictory conditions: ensuring reliable, high-throughput measurements and being open to innovations. At the University of Basel, Dr. Alessandro Prescimone balances these two conditions with three diffractometers, each dedicated to a different scope: high-throughput samples, difficult structures, or teaching. With these, Alessandro optimizes time and experimental conditions for each user group: internal departments, industry users, and students who are involved in crystallography courses.